Endometrial dating infertility

The mucous membrane comprising the inner layer of the uterine wall; it consists of a simple columnar epithelium and a lamina propria that contains simple tubular uterine glands.The structure, thickness, and state of the endometrium undergo marked change with the menstrual cycle.The utility of histological dating of endometrium in the evaluation of infertile couples is uncertain.DESIGN: Prospective multicenter study, with subjects randomly assigned to biopsy timing.We use cookies to make interactions with our website easy and meaningful, to better understand the use of our services, and to tailor advertising.For further information, including about cookie settings, please read our Cookie Policy .Fertile controls were excluded if they had a history of infertility, recurrent pregnancy loss, or recent breastfeeding.

The stratum compactum and the stratum spongiosum constitute the pars functionalis and are shed with each menstrual flow.After detection of the LH surge, subjects were randomized to biopsy in the mid (days 21-22) or the late (days 26-27) luteal phase.Pathologists at each site estimated the cycle day based on standard criteria.We have verified the Noyes criterion in natural cycle in previous study which conducting endometrial biopsies respectively on day 3, 5, 7, 9 and 11 of post-ovulation (PO 3/5/7/9/11)(unpublished data).The clinical value of the endometrial histological dating in RIF patients in natural cycle is still to be answered.

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